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Protocol Summary and Purpose of this Study:   This is a randomized, open-label, two-arm (phase IIa) study of ruxolitinib in HIV-infected adults. Eligible participants on select antiretroviral therapy (ART) with virologic suppression will be randomized to receive ruxolitinib or no study treatment to measure safety, tolerability, PK and to determine whether […]

A5336: A Study of Ruxolitinib in ART-Treated HIV-1 Infected Adults





A clinical trial of low-dose methotrexate on inflammation in HIV-infected people who are at risk for cardiovascular disease (CVD): A5314. https://actgnetwork.org/study/a5314-mtx-hiv-positives Brief Summary and Purpose of this study: Anti-HIV medicines have been very successful in allowing people with HIV to control the virus. However, researchers have noticed that many patients have […]

A5314: Effects of methotrexate on inflammation in poz folks at ...



A Phase 2B clinical trial to evaluate the safety and drug levels of a human monoclonal antibody (VRC01) administered in multiple doses intravenously and subcutaneously in different dosing schedules to healthy, HIV-uninfected adults. This strategy is called passive immunization, or antibody-mediated prevention (AMP).   Purpose of the Study Primary objective 1: To evaluate the […]

AMP Study: A Passive Immunization Clinical Trial for HIV-Negative Adults


Common herpes medication reduces HIV-1 levels, independent of herpes infection March 16, 2015 in Case Daily, from Clinical Infectious Diseases http://thedaily.case.edu/news/common-herpes-medication-reduces-hiv-1-levels-independent-of-herpes-infection/ Case Western Reserve researchers play a key role in clinical trials’ groundbreaking results. ACTU co-principal investigators Benigno Rodriguez and Michael Lederman are part of an international team that discovered […]

Common herpes med reduces HIV



Case Western Reserve University, Population Genetics Technologies form HIV research partnership March 12, 2015 in Crain’s Cleveland Business http://www.crainscleveland.com/article/20150312/FREE/150319937/case-western-reserve-university-population-genetics-technologies A British company developing a way to spot mutations in the HIV virus has formed a partnership with Case Western Reserve University. The university will help Population Genetics Technologies develop tests […]

CWRU HIV researchers develop way to spot mutations


Community plays key role in testing a modified version of ‘Thai vaccine’ regimen Feb. 18, 2015 — Fred Hutch News Service http://www.fredhutch.org/en/news/center-news/2015/02/hiv-vaccine-clinical-trial-launches-in-south-africa.html A much-anticipated clinical trial has begun in South Africa to test a modied version of the so-called Thai vaccine, the only experimental vaccine regimen so far to show […]

CAB members are a bridge between researchers and the community



AmeriCorps Team Cleveland presents Conscious Creations The AmeriCorps team’s long-term project is under way with the kick-off of their art competition for high school students, called Conscious Creations. The submission flyer and application are attached below, along with HIV facts and a list of testing & services sites in Cleveland. […]

AmeriCorps HIV art competition


Presenting Back on Board: Greg Louganis Again this year, the ACTU partners with the Cleveland International Film Festival, presenting a new documentary by Cheryl Furjanic about four-time Olympic gold medalist diver Greg Louganis, and his struggles with HIV and being an openly gay athlete. Find info, trailer and tickets here: […]

Cleveland International Film Festival