Brooke Willis



Researcher at Frances Payne Bolton School of Nursing focuses on aging-related health issues among people living with HIV-AIDS Nurse scientist Allison Webel, PhD at Case Western Reserve University is further expanding her research on aging-related health challenges increasingly faced by people living longer with HIV-AIDS. Her ongoing NIH-funded work investigating […]

CWRU Nurse Scientist Studies Aging Well with HIV




Promising HIV vaccine to be tested with gay men and trans people This article is a helpful overview of Mosaico, a global HIV-prevention vaccine study enrolling 3,800 sexually active HIV-negative gay men and transgender people age 18-60.   Article: http://www.aidsmap.com/news/jul-2019/promising-hiv-vaccine-be-tested-gay-men-and-trans-people  Study: https://clinicaltrials.gov/ct2/show/NCT03964415

Mosaico HIV-prevention vaccine study opening soon



Trailblazer studies gene-editing HIV treatment at 3 sites Dr. Carl Fichtenbaum at our sister site at the University of Cincinnati talks about #Trailblazer, our HIV treatment study using zinc finger nucleases to perform gene editing on cells to reduce the reservoir of HIV infection. Link: https://www.uc.edu/news/articles/2019/08/n20848753.html

Carl Fichtenbaum’s UofC IDRU takes on gene editing to reduce ...




The primary purpose of this study is to compare the size of the participants’ HIV latent reservoirs before and after receiving 8 cycles of IL-2. In order to measure the size of the HIV reservoir, all participants will undergo a leukapheresis procedure prior to taking IL-2. These results will be compared with results from another leukapheresis procedure after the participant completes theIL-2 cycles.

AIDS 400: An open-label pilot study of HIV reservoir reduction ...


CWRU’s Blanton Tolbert appointed to NIH Office of AIDS Research Advisory Council (OARAC) June 3, 2019 Congratulations to CWRU chemistry associate professor and HIV researcher Blanton Tolbert, who was appointed to the National Institutes of Health’s Office of AIDS Research Advisory Council, a permanent position that advises on the direction […]

CWRU’s Blanton Tolbert appointed to NIH Office of AIDS Research ...



Latitude Study A5359: Long-acting injectable anti-HIV medicine April 30, 2019 The CWRU/UH AIDS Clinical Trials Unit announced today the opening of a new clinical trial for people living with HIV called the Latitude study. The study will be the first in northeast Ohio to use long-acting, injectable anti-HIV medicines. The […]

Latitude Study A5359: Long-acting, injectable ART




Protocol Summary: Trio (ACTG5377) is a Phase I, first-in-human, ascending-dose study of a tri-specific broadly neutralizing antibody, in participants living with HIV. This trial will look at a human-made antibody called SAR441236. Unlike the antibodies created by a person’s immune system that attach to HIV at one part, SAR441236 has […]

Trio A5377: A Phase I, first-in-human, ascending-dose study of a ...





Protocol Summary: This study will compare the use of long-acting, injectable anti-HIV medicines with anti-HIV medicines in daily pill form for people living with HIV who have not been previously adherent (keeping up) with their anti-HIV medicines in daily pill form. Purpose of This Study: Anti-HIV medicines taken as pills […]

Latitude A5359: To see if long-acting, injectable ARTs are helpful ...



Community Advisory Board (CAB) meetings, Awareness Days & Other Events  Visit our Facebook (www.facebook.com/clevelandclinicaltrials) and Twitter (twitter.com/CLEHIVtrials) pages for updates. JANUARY 8: CAB MEETING January 23: Bruce Richman, U=U / Prevention Access Campaign, visiting Cleveland February: American Heart Month February 7: National Black HIV/AIDS Awareness Day FEBRUARY 12: CAB MEETING […]

2019 Calendar of Events





New documentary about the Columbus drag community All are welcome to a free screening of Kings, Queens, & In-Betweens about the Columbus drag community at 5:30pm on Friday, October 5 at the Wolstein Research Building, 2103 Cornell Rd in University Circle, Cleveland. LGBTQ organizations will have information tables during a reception […]

Free screening of Kings, Queens, & In-Betweens Oct. 5






Sékaly to study genetically engineering immune cells for HIV treatment CWRU School of Medicine researcher and professor of pathology Rafick-Pierre Sékaly received an $11 million grant from the National Institutes of Health and will partner with Sangamo Therapeutics to study the possibility of eradicating HIV in people living with the virus. […]

CWRU researcher receives $11 million grant to study HIV treatment


AIDS Funding Collaborative funded study of non-occupational PEP resources (nPEP) The AIDS Funding Collaborative (a program of the The Center for Community Solutions) funded a study by a CWRU/UH medical school student and an ER doctor to look at the need for non-occupational exposure PEP (nPEP) resources in emergency departments. Similar […]

Study of nPEP resources in emergency rooms



CWRU’s Sékaly Finds HIV Reservoir Vulnerability  Today the Case Daily published an article about exciting developments in purging the reservoir of infected immune cells in people living with HIV, research conducted by our CFAR colleague Rafick-Pierre Sékaly. A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could “purge” the reservoir […]

CWRU researchers find HIV reservoir vulnerability





CDC Joins Consensus that U Equals U   September 29, 2017 by Savas Abadsidis from Plus.com On National Gay Men’s HIV/AIDS Awareness Day, the CDC released a history-making statement with updated language on viral suppression and transmission risk. “That is a remarkable statement,” as Bruce Richman, executive director of the Prevention Access Campaign’s Undetectable=Untransmittable campaign […]

CDC joins consensus that Undetectable Equals Untransmittable




Gilead Sciences awards $2.5 million to CWRU AIDS Clinical Trials Unit February 1, 2017: Gilead Sciences awarded CWRU School of Medicine’s Michael M. Lederman, MD to study HIV Reservoir Reduction with Interleukin-2 and monoclonal antibody treatments. IL-2 and certain monoclonal antibodies have been shown separately to reduce the presence of HIV, […]

Lederman gets $2.5M Gilead grant to study one-two punch



Over $22M in Grants from Gilead to Study HIV Cure Research January 11, 2017: Gilead awards over $22 million to a dozen HIV cure research projects. Case Western Reserve University School of Medicine’s Michael M. Lederman, MD to study Reservoir Reduction with Interleukin-2 and Transcriptional Activation. https://www.poz.com/article/22m-grants-gilead-study-three-areas-hiv-cure-research  

Gilead funds CWRU cure research


HIV is not a crime
Ohio Supreme Court Will Review Felony HIV Exposure Law & Conviction October 5, 2016: The Center for HIV Law and Policy and the ACLU of Ohio Foundation submitted a brief supporting the petition for Ohio Supreme Court review of State of Ohio v. Orlando Batista, arguing that Ohio’s felonious assault […]

HIV Is Not a Crime



Mort Mandel commits $100,000 for outstanding chemistry faculty award Yet again, Mandel has chosen to live his principles in his charitable giving. Through the Morton and Barbara Mandel Family Foundation, he committed $100,000 for the Morton L. Mandel Award endowment. The annual award will honor and reward outstanding faculty members […]

Blanton Tolbert awarded inaugural Mandel endowment





Links to protocol summaries of current & upcoming clinical trials at the Case site March 2019 Coming Soon: 5359:  A phase III randomized, cross-over study to evaluate long-acting injectable antiretroviral therapy for people living with HIV who have not been adherent to their antiretroviral therapy in pill form. A5359 Provider […]

Protocol Summaries






Special Immunology Unit director and PrEP Clinic founder Barbara Gripshover, MD http://medicine.case.edu/department-newsletter/february-2016-newsletter Barbara Gripshover, MD, Medical Director of the John T. Carey Special Immunology Unit (SIU) at University Hospitals Case Medical Center, and founder of the area’s first PrEP Clinic, examines common barriers to engaging patients with HIV in health […]

Barbara Gripshover, SIU director


School of Nursing’s Allison Webel contributes to 4th edition http://thedaily.case.edu/news/as-hiv-patients-live-longer-updated-guide-helps-patients-navigate-new-territory/ The Case Daily reports that Frances Payne Bolton School of Nursing professor and HIV researcher Allison Webel is part of a team that has updated a patient guide for HIV care, treatment and how to communicate with family, friends and others about […]

HIV Book Updated by CWRU’s Allison Webel






Inaugural appointment The CWRU School of Medicine advances its legacy of HIV research innovation and collaboration by bringing on Rafick-Pierre Sékaly, PhD, one of the world’s leading scientists in AIDS research, human immunology and immunotherapy, as the inaugural Richard J. Fasenmyer Professor of Immunopathogenesis. Read more at http://thedaily.case.edu/news/?p=41184 More information about the Fasenmyer […]

Leading AIDS researcher appointed to Fasenmyer Professorship in School of ...