Brooke Willis

$3.25M NIH grant to support research in oral manifestations of HIV, including mouth cancer Researchers at the Case Western Reserve University School of Dental Medicine will use a $3.25 million grant from the National Institutes of Health (NIH) to better understand how HIV impacts the human body, from mouth lesions to oral […]

Case Dental gets $3.25M NIH grant to support research in ...

 in News  tagged A5383 / anti-CMV / CMV / CMV and HIV / cmv disease / ELICIT Study / HIV / letermovir by
ACTG launches A5383, clinical trial evaluating potential immunologic benefits of treating asymptomatic CMV in people living with HIV The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, today announced the initiation of A5383, a clinical trial evaluating whether the anti- cytomegalovirus (CMV) drug letermovir reduces inflammation when […]

A5383: ELICIT clinical trial of anti-CMV medication letermovir

 in News  tagged A5383 / anti-CMV / CMV / CMV and HIV / cmv disease / ELICIT Study / HIV / letermovir by
Injectable PrEP highly successful, despite HIV infections Experts say breakthrough HIV should still remain rare in those receiving ViiV Healthcare’s injectable Apretude to prevent infection. In a large clinical trial assessing Apretude, ViiV Healthcare’s recently approved injectable drug, as a form of HIV prevention, seven participants contracted the virus despite […]

Breakthrough HIV reported in injectable PrEP trial; experts say drug ...

 in News  tagged HIV / HIV prevention / injectable PrEP / long-acting HIV prevention / long-acting injectable / long-acting PrEP / PrEP by
CROI2022 overview w/Dr. Carl Dieffenbach, head of NIAID NIAID director Dr. Carl Dieffenbach reviews updates from #CROI2022 (www.croiconference.org) in this 34-minute video. In an HIV.gov video conversation on Wednesday, February 16, NIH’s Dr. Carl Dieffenbach discussed some of the pivotal HIV research advances presented this week at the 2022 virtual […]

NIH’s Dr. Carl Dieffenbach Discusses Highlights of HIV Cure, Treatment ...

 in News  tagged CROI / CROI2022 / cure / Dieffenbach / HIV / hiv cure / HIV prevention / HIV treatment by
COVID numbers down but immunocompromised still at risk COVID-19 cases are the lowest they have been in Cuyahoga County in months, and many schools and businesses are no longer requiring masks. But for people with compromised immune systems, like Lakewood resident Robert Toth, this is a difficult environment to navigate. In […]

Immunocompromised are still at risk as COVID-19 cases plummet in ...

 in News  tagged covid / COVID prevention / COVID-19 / HIV / immunocompromised by
Participant Summary Click here for a printable participant summary.   Title: A5355 – Phase II, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-based anti-Cytomegalovirus (CMV) Vaccine (Triplex®), in Adults with Both Human Immunodeficiency Virus (HIV)-1 and CMV Who Are on Potent Combination ART […]

A5355: a clinical trial of an anti-CMV vaccine

 in Clinical Trials / People Living With HIV  tagged CMV / CMV vaccine / cytomegalovirus / HIV research / HIV treatment / HIV treatment study / People Living With HIV / Triplex by
Biden administration to buy Pfizer antiviral pills for 10 million people, hoping to transform COVID-19 pandemic Pfizer, meanwhile, asks regulators to authorize the pills and agrees to allow them to be made and sold for less in poor countries. The Biden administration is planning to purchase 10 million courses of Pfizer’s […]

Biden administration to buy Pfizer antiviral pills for 10 million ...

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SAB-185 Polyclonal Antibody Graduates to Phase 3 The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, announced that SAB-185, a novel polyclonal antibody therapy, has demonstrated safety and efficacy in phase 2 that meet the […]

ACTG Announces Graduation of Novel Polyclonal Antibody Therapy SAB-185 to ...

 in News  tagged HIV / HIV research / HIV vaccine / HVTN705 / Imbokodo by
Title: A5391: Doravirine for Persons with Excessive Weight Gain while taking Integrase Inhibitors and Tenofovir Alafenamide (TAF): The DO-IT Study Click here for printable participant summary. Description: Weight gain after starting anti-HIV medicines is common, but recent studies have found that taking certain medicines may cause increased weight more than […]

A5391: Doravirine for Persons with Excessive Weight Gain on Integrase ...

 in Clinical Trials / People Living With HIV  tagged Doravirine / HIV belly / HIV research / HIV TAF / HIV treatment / HIV treatment study / HIV weight gain / People Living With HIV by
Title: A5386: Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control in the Reservoirs During Analytic Treatment Interruption Purpose: Researchers are looking for ways to get rid of HIV that rests hidden in areas of the body (reservoirs) where current […]

A5386, a clinical trial to control HIV in a new ...

 in Clinical Trials / People Living With HIV  tagged analytic treatment interruption / HIV control / HIV research / HIV reservoir / HIV treatment / HIV treatment study / latent / People Living With HIV / reservoir by
Title: A5379 BEEHIVE B-Enhancement of HBV Vaccination in Persons Living with HIV (BEe-HIVe) Description Hepatitis B is a serious viral infection that affects the liver and is transmitted through blood and body fluids. Although there is a vaccination for hepatitis B, sometimes the vaccines do not work well for people […]

A5379: BEEHIVE, a Hepatitis-B Vaccine Study for People Living with ...

 in Clinical Trials / People Living With HIV  tagged BEEHIVE / Hep-B / Hep-B and HIV / Hepatitis B / HIV treatment study / People Living With HIV / vaccination by
Nominations are open for the annual Marilyn Kuczynski Faith & Strength Award National Faith HIV/AIDS Awareness Day (NFHAAD) was founded by Khadijah Abdullah in 2016. She is also the founder of RAHMA (Reaching All HIV+ Muslims in America), an Islamic organization in Arabic (the name means Mercy). In 2016, advocates […]

Marilyn Kuczynski Faith & Strength Award nominations open

 in News  tagged faith and HIV / HIV / HIV activist / HIV advocate / hiv cure / Marilyn Kuczynski by
HIV cure–related research focus group of serodiscordant couples A message from HIV researchers Danielle M. Campbell, Charles R. Drew University of Medicine and Science, Los Angeles, CA, and Karine Dubé, UNC Gillings School of Global Public Health, Chapel Hill, NC about their research on HIV cure research with HIV-discordant couples: […]

HIV cure focus group/interview study

 in News  tagged discordant / HIV / HIV couples / hiv cure / HIV focus group / HIV research / serodiscordant by
CWRU/UH Site Enrolls for COVID-19 Prevention Vaccine One of the sites for the federal Operation Warp Speed COVID-19 prevention vaccine studies is our Clinical Trials Unit in Cleveland, overseen by the newly formed Coronavirus Prevention Network. We expect to open the AstraZeneca vaccine study (CoVPN3002/AZD1222) soon and begin enrolling adults […]

Phase 3 Clinical Testing of AstraZeneca COVID-19 Vaccine Candidate Begins

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Advanced Management Issues in HIV Care – Sep. 17 & 18 presented by the Sarah Cole Hirsh Institute of Evidence-Based Practice A focus on management of patients living with HIV. Who should attend: Infectious disease and internal medicine physicians, nurse practitioners, physician assistants, pharmacists, nurses and other health care professionals […]

Save the Date: Advanced Management Issues in HIV Care 2020

 in News  tagged HIV care / HIV docs / HIV education / HIV management / HIV nurses / HIV seminar / HV treatment by
Research during a Pandemic We sent out our March e-newsletter on Friday, with updates on COVID-19, the virtual CROI sessions, HIV-related webinars, our clinical trials for prevention and treatment, Community Advisory Board news, HIV decriminalization efforts, and working from home tips, which you can read here: https://mailchi.mp/6f21d1df3f67/1244361-1411173 Please share with […]

Research during a Pandemic – our e-news for March

 in News  tagged CAB / coronavirus / covid19 / CROI sessions / hiv studies / HIV webinars / pandemic / working from home by
City Club Virtual Forum w/John Corlett FEATURING: John R. Corlett, President and Executive Director, The Center for Community Solutions and longtime HIV/AIDS advocate Over the last few weeks, Governor Mike DeWine and Ohio Director of Health Dr. Amy Action have signed a number of orders to curb the spread of coronavirus. […]

City Club Virtual Forum: State Policy During a Pandemic w/John ...

 in News  tagged coronavirus / covid19 / John Corlett / Ohio / pandemic / policy by
Researcher at Frances Payne Bolton School of Nursing focuses on aging-related health issues among people living with HIV-AIDS Nurse scientist Allison Webel, PhD at Case Western Reserve University is further expanding her research on aging-related health challenges increasingly faced by people living longer with HIV-AIDS. Her ongoing NIH-funded work investigating […]

CWRU Nurse Scientist Studies Aging Well with HIV

 in News  tagged aging / Allison Webel / depression / HIV / living well / neurocognitive / research by
Promising HIV vaccine to be tested with gay men and trans people This article is a helpful overview of Mosaico, a global HIV-prevention vaccine study enrolling 3,800 sexually active HIV-negative gay men and transgender people age 18-60.   Article: http://www.aidsmap.com/news/jul-2019/promising-hiv-vaccine-be-tested-gay-men-and-trans-people  Study: https://clinicaltrials.gov/ct2/show/NCT03964415

Mosaico HIV-prevention vaccine study opening soon

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Trailblazer studies gene-editing HIV treatment at 3 sites Dr. Carl Fichtenbaum at our sister site at the University of Cincinnati talks about #Trailblazer, our HIV treatment study using zinc finger nucleases to perform gene editing on cells to reduce the reservoir of HIV infection. Link: https://www.uc.edu/news/articles/2019/08/n20848753.html

Carl Fichtenbaum’s UofC IDRU takes on gene editing to reduce ...

 in News  tagged AIDS / gene-editing / HIV / reservoir / Trailblazer / zinc-finger by
CWRU’s Blanton Tolbert appointed to NIH Office of AIDS Research Advisory Council (OARAC) June 3, 2019 Congratulations to CWRU chemistry associate professor and HIV researcher Blanton Tolbert, who was appointed to the National Institutes of Health’s Office of AIDS Research Advisory Council, a permanent position that advises on the direction […]

CWRU’s Blanton Tolbert appointed to NIH Office of AIDS Research ...

 in News  tagged AIDS / chemistry / HIV / NIH / OARAC / RNA by
Latitude Study A5359: Long-acting injectable anti-HIV medicine April 30, 2019 The CWRU/UH AIDS Clinical Trials Unit announced today the opening of a new clinical trial for people living with HIV called the Latitude study. The study will be the first in northeast Ohio to use long-acting, injectable anti-HIV medicines. The […]

Latitude Study A5359: Long-acting, injectable ART

 in News  tagged injectable / LA-ART / long-acting / monthly / non-adherent / People Living With HIV by
Protocol Summary: This study will compare the use of long-acting, injectable anti-HIV medicines with anti-HIV medicines in daily pill form for people living with HIV who have not been previously adherent (keeping up) with their anti-HIV medicines in daily pill form. Purpose of This Study: Anti-HIV medicines taken as pills […]

Latitude A5359: To see if long-acting, injectable ARTs are helpful ...

 in Clinical Trials / People Living With HIV  tagged non-adherent / People Living With HIV by
Community Advisory Board (CAB) meetings, Awareness Days & Other Events  Visit our Facebook (www.facebook.com/clevelandclinicaltrials) and Twitter (twitter.com/CLEHIVtrials) pages for updates. JANUARY 8: CAB MEETING January 23: Bruce Richman, U=U / Prevention Access Campaign, visiting Cleveland February: American Heart Month February 7: National Black HIV/AIDS Awareness Day FEBRUARY 12: CAB MEETING […]

2019 Calendar of Events

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New documentary about the Columbus drag community All are welcome to a free screening of Kings, Queens, & In-Betweens about the Columbus drag community at 5:30pm on Friday, October 5 at the Wolstein Research Building, 2103 Cornell Rd in University Circle, Cleveland. LGBTQ organizations will have information tables during a reception […]

Free screening of Kings, Queens, & In-Betweens Oct. 5

 in News  tagged Columbus / Columbus drag / documentary / drag / drag kings / drag queens / Gabrielle Burton by
Sékaly to study genetically engineering immune cells for HIV treatment CWRU School of Medicine researcher and professor of pathology Rafick-Pierre Sékaly received an $11 million grant from the National Institutes of Health and will partner with Sangamo Therapeutics to study the possibility of eradicating HIV in people living with the virus. […]

CWRU researcher receives $11 million grant to study HIV treatment

 in News  tagged geneticengineering / HIVcure / HIVeradication / HIVreservoir / HIVtreatment / Sangamo by
AIDS Funding Collaborative funded study of non-occupational PEP resources (nPEP) The AIDS Funding Collaborative (a program of the The Center for Community Solutions) funded a study by a CWRU/UH medical school student and an ER doctor to look at the need for non-occupational exposure PEP (nPEP) resources in emergency departments. Similar […]

Study of nPEP resources in emergency rooms

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CWRU’s Sékaly Finds HIV Reservoir Vulnerability  Today the Case Daily published an article about exciting developments in purging the reservoir of infected immune cells in people living with HIV, research conducted by our CFAR colleague Rafick-Pierre Sékaly. A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could “purge” the reservoir […]

CWRU researchers find HIV reservoir vulnerability

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CDC Joins Consensus that U Equals U   September 29, 2017 by Savas Abadsidis from Plus.com On National Gay Men’s HIV/AIDS Awareness Day, the CDC released a history-making statement with updated language on viral suppression and transmission risk. “That is a remarkable statement,” as Bruce Richman, executive director of the Prevention Access Campaign’s Undetectable=Untransmittable campaign […]

CDC joins consensus that Undetectable Equals Untransmittable

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Gilead Sciences awards $2.5 million to CWRU AIDS Clinical Trials Unit February 1, 2017: Gilead Sciences awarded CWRU School of Medicine’s Michael M. Lederman, MD to study HIV Reservoir Reduction with Interleukin-2 and monoclonal antibody treatments. IL-2 and certain monoclonal antibodies have been shown separately to reduce the presence of HIV, […]

Lederman gets $2.5M Gilead grant to study one-two punch

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Over $22M in Grants from Gilead to Study HIV Cure Research January 11, 2017: Gilead awards over $22 million to a dozen HIV cure research projects. Case Western Reserve University School of Medicine’s Michael M. Lederman, MD to study Reservoir Reduction with Interleukin-2 and Transcriptional Activation. https://www.poz.com/article/22m-grants-gilead-study-three-areas-hiv-cure-research  

Gilead funds CWRU cure research

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HIV is not a crime
Ohio Supreme Court Will Review Felony HIV Exposure Law & Conviction October 5, 2016: The Center for HIV Law and Policy and the ACLU of Ohio Foundation submitted a brief supporting the petition for Ohio Supreme Court review of State of Ohio v. Orlando Batista, arguing that Ohio’s felonious assault […]

HIV Is Not a Crime

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Mort Mandel commits $100,000 for outstanding chemistry faculty award Yet again, Mandel has chosen to live his principles in his charitable giving. Through the Morton and Barbara Mandel Family Foundation, he committed $100,000 for the Morton L. Mandel Award endowment. The annual award will honor and reward outstanding faculty members […]

Blanton Tolbert awarded inaugural Mandel endowment

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Links to protocol summaries of current & upcoming clinical trials at the Case site February 2020 5359: Latitude, a phase III, randomized, cross-over study to evaluate long-acting injectable antiretroviral therapy for people living with HIV who have not been adherent to their antiretroviral therapy in pill form. Latitude A5359 Provider […]

Protocol Summaries

 in For Doctors by
Special Immunology Unit director and PrEP Clinic founder Barbara Gripshover, MD http://medicine.case.edu/department-newsletter/february-2016-newsletter Barbara Gripshover, MD, Medical Director of the John T. Carey Special Immunology Unit (SIU) at University Hospitals Case Medical Center, and founder of the area’s first PrEP Clinic, examines common barriers to engaging patients with HIV in health […]

Barbara Gripshover, SIU director

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School of Nursing’s Allison Webel contributes to 4th edition http://thedaily.case.edu/news/as-hiv-patients-live-longer-updated-guide-helps-patients-navigate-new-territory/ The Case Daily reports that Frances Payne Bolton School of Nursing professor and HIV researcher Allison Webel is part of a team that has updated a patient guide for HIV care, treatment and how to communicate with family, friends and others about […]

HIV Book Updated by CWRU’s Allison Webel

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Inaugural appointment The CWRU School of Medicine advances its legacy of HIV research innovation and collaboration by bringing on Rafick-Pierre Sékaly, PhD, one of the world’s leading scientists in AIDS research, human immunology and immunotherapy, as the inaugural Richard J. Fasenmyer Professor of Immunopathogenesis. Read more at http://thedaily.case.edu/news/?p=41184 More information about the Fasenmyer […]

Leading AIDS researcher appointed to Fasenmyer Professorship in School of ...

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