Clinical Trials

Welcome to the AIDS Clinical Trials Unit at Case Western Reserve University / University Hospitals Case Medical Center (Case ACTU). For over 24 years the Case ACTU has been a worldwide leader in HIV/AIDS-related clinical research. This success has been possible because of the thousands of volunteers from Cleveland and Northeast Ohio who have taken part in our clinical trials.

The Case ACTU offers a wide variety of clinical trials for HIV-positive and HIV-negative people. New trials are regularly added to those being offered. Case ACTU staff members are available to talk with you about these trials.

Through its Community Advisory Board, other community partners and sponsored events, the Case ACTU offers many educational opportunities to learn more about HIV prevention, treatment and clinical research. If you have any questions, comments or would like to be added to our email newsletter list, please do not hesitate to contact us.

 Protocol Summary:  This is a phase IV randomized, double-blinded, placebo-controlled study to assess the efficacy of adding maraviroc (MVC) and dolutegravir (DTG) to the current antiretroviral therapy (ART) of HIV-infected individuals who have at least mild neurocognitive impairment with a primary outcome of improvement in neurocognitive performance. Purpose of This […]

A5324: To see if adding extra anti-HIV medicines reduces HIV-associated ...

Protocol Summary and Purpose of this Study:   This is a randomized, open-label, two-arm (phase IIa) study of ruxolitinib in HIV-infected adults. Eligible participants on select antiretroviral therapy (ART) with virologic suppression will be randomized to receive ruxolitinib or no study treatment to measure safety, tolerability, PK and to determine whether […]

A5336: A Study of Ruxolitinib in ART-Treated HIV-1 Infected Adults

A clinical trial of low-dose methotrexate on inflammation in HIV-infected people who are at risk for cardiovascular disease (CVD): A5314. Brief Summary and Purpose of this study: Anti-HIV medicines have been very successful in allowing people with HIV to control the virus. However, researchers have noticed that many patients have […]

A5314: Effects of methotrexate on inflammation in poz folks at ...

A Phase 2B clinical trial to evaluate the safety and drug levels of a human monoclonal antibody (VRC01) administered in multiple doses intravenously and subcutaneously in different dosing schedules to healthy, HIV-uninfected adults. This strategy is called passive immunization, or antibody-mediated prevention (AMP).   Purpose of the Study Primary objective 1: To evaluate the […]

AMP Study: A Passive Immunization Clinical Trial for HIV-Negative Adults