HIV treatment study


Title: AIDS 392: TRAILBLAZER, elimination of CCR5 receptors with zinc finger to prevent viral replication, in participants living with HIV Purpose: The main purpose of this study is to test a new type of strategy to treat HIV: giving people living with HIV genetically modified versions of their own CD4+ […]

AIDS 392: TRAILBLAZER, elimination of CCR5 receptors with zinc finger ...


The primary purpose of this study is to compare the size of the participants’ HIV latent reservoirs before and after receiving 8 cycles of IL-2. In order to measure the size of the HIV reservoir, all participants will undergo a leukapheresis procedure prior to taking IL-2. These results will be compared with results from another leukapheresis procedure after the participant completes theIL-2 cycles.

AIDS 400: STARR, An open-label pilot study of HIV reservoir ...



Protocol Summary: Trio (ACTG5377) is a Phase I, first-in-human, ascending-dose study of a tri-specific broadly neutralizing antibody, in participants living with HIV. This trial will look at a human-made antibody called SAR441236. Unlike the antibodies created by a person’s immune system that attach to HIV at one part, SAR441236 has […]

Trio A5377: A Phase I, first-in-human, ascending-dose study of a ...